Welcome to the sixth installment in our series of mini articles on various aging pathways. This article explores TFEB, a transcription factor, and its vital role in regulating cellular health and longevity through its impact on autophagy and lysosomal biogenesis. Read on for a brief overview of TFEB’s function and the nutrient-sensing pathways contributing to healthy aging.
This article is part six of a ten-part series on reproductive aging.
- How Do Growth Pathways & Nutrient Sensing Impact Our Aging?
- Nurturing Resilience Against Molecular Damage
- Harnessing Hormesis and Mitohormesis for Longevity
- The Nrf2 Pathway and Iron’s Impact on Aging and Cancer
- The Role of Repair and Recycling in Longevity
- Enhancing Longevity Through TFEB Activation and Nutrient Sensing
- Epigenetic Reprogramming: A Gateway to Youth
- The Importance of Telomerase: Extending Chromosomal Integrity
- The Impact of LDL Cholesterol and ApoE on Longevity
- Lifestyle Factors and Their Role in Promoting Longevity
TFEB: Master Regulator of Autophagy
TFEB regulates gene expression in lysosomal biogenesis and autophagy, processes essential for cellular maintenance. Activated by pathways such as mTOR inhibition and AMPK activation, TFEB enhances the cell’s ability to degrade and recycle damaged components, supporting longevity. Evidence suggests that higher TFEB levels are associated with increased lifespan and improved cellular health.
Nutrient Sensing and Longevity Pathways
Nutrient sensing pathways play a pivotal role in aging by regulating cellular responses to nutrient availability. Calorie restriction and fasting are well-known interventions that activate these pathways, promoting autophagy and enhancing stress resistance. These interventions mimic the effects of nutrient scarcity, triggering beneficial cellular responses that support longevity.
Supplements and Lifestyle Interventions
Supplements like pterostilbene and fisetin, both included in NOVOS Core, can activate TFEB, promoting autophagy and cellular renewal. Additionally, lifestyle interventions such as calorie restriction and intermittent fasting can enhance nutrient-sensing pathways, supporting healthy aging. Incorporating these strategies can help maintain cellular health and extend lifespan.
TFEB and Nutrient Sensing for Healthy Aging
Activating TFEB and optimizing nutrient-sensing pathways are promising strategies for promoting longevity and maintaining cellular health. By incorporating supplements and lifestyle interventions that support these pathways, we can enhance our resilience to aging and improve overall well-being. For a detailed exploration of these concepts, refer to the complete article, The Pathways of Aging: Repair and Recycling.
