As we age, our body’s capacity to repair DNA and maintain cellular vitality diminishes, leading to signs of aging and health issues.
Nicotinamide Mononucleotide (NMN) plays a pivotal role in this process. A natural substance in the body, NMN is essential for producing NAD+, a critical molecule needed by every cell.
NAD+ is crucial for countless enzymes and proteins, particularly those involved in repairing and maintaining our DNA and epigenome, such as sirtuins and PARPs, underscoring NMN’s potential in enhancing longevity and cellular health (R).
Benefits of NMN:
As an anti-aging powerhouse, NMN (Nicotinamide Mononucleotide) offers several benefits that promote health and longevity. Below, we’ve listed eight powerful benefits of NMN to longevity and overall health.
1. NMN increases energy levels
Many people notice an increase in energy as a benefit after taking NMN. While 250 mg may suffice for most, some might need at least 500 mg to experience the benefits.
Research on older mice has demonstrated that NMN can significantly enhance stamina and endurance, with improvements of up to 80% noted from oral supplementation (R,R).
2. NMN improves memory
Many people who take NMN report improved cognitive function, feeling sharper and more focused. Research supports these benefits, indicating that NMN improves brain functions like thinking and blood circulation in studies conducted on mice. This suggests that NMN could help clear your mind and enhance your brain health (R).
Source: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology, 2019
Source: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology, 2019
3. NMN & healthier blood vessels
Another benefit of NMN is its impact on blood vessels. NMN has shown promising results in rejuvenating aged blood vessels, significantly enhancing their elasticity in older animals:
Source: Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell, 2016
Additionally, NMN helps maintain healthier mitochondria in endothelial cells, which is crucial for cellular energy production and overall vascular function.
Source: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology, 2019
4. NMN improves metabolism
NMN enhances metabolism, which is crucial since our metabolism slows down as we age, leading to a higher risk of diseases. Studies have shown that NMN can help reduce insulin resistance, improve blood lipid levels, and prevent age-related weight gain.
It also boosts physical activity. These improvements are essential for maintaining health as we age and reducing disease risk (R,R,R,R).
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5. NMN improves aging-associated decline in elderly organisms
As we age, our eyesight, stamina, energy levels, bone density, and immune function typically decline. However, studies involving older mice have shown that NMN supplementation can improve these aspects of health.
Benefits observed include less weight gain, enhanced metabolism, more physical activity, and better insulin sensitivity and eye function. NMN also positively influences aging-related gene expression, mitochondrial efficiency, and muscle protein balance, highlighting its potential as an effective anti-aging supplement (R,R).
6. NMN improves fertility
NMN has also been linked to improved fertility, with some users reporting a boost in libido. Research and biotech findings indicate that NMN and its derivatives can restore fertility in aged animals (R).
Learn more here.
7. NMN improves stem cell health
Aging affects stem cell health, leading to a decrease in their numbers and function, which is critical since stem cells regenerate new cells and maintain tissues. Research indicates that NMN, by increasing NAD levels, can enhance the health and self-renewal capabilities of stem cells, offering potential benefits against the natural decline associated with aging (R,R,R,R).
8. NMN repairs DNA damage
One of the reasons we get older is because of DNA damage, and studies have shown that NMN can help cells repair their damaged DNA.
Specifically, in one study, mice that were given NMN had significantly less DNA damage (as measured by alpha-H2AX, a biomarker for DNA damage):
Source: A conserved NAD+ binding pocket that regulates protein-protein interactions during aging, Science, 2017
In an experiment, irradiated mice usually experience significant DNA damage and a loss of red blood cells. However, when these mice were treated with NMN, they maintained higher levels of red blood cells than those untreated, as evidenced by their hemoglobin levels. This suggests that NMN can protect against cellular damage typically caused by radiation.
Source: A conserved NAD+ binding pocket that regulates protein-protein interactions during aging, Science, 2017
Many other studies show that NMN benefits aging, often even reversing specific aging conditions in old animals to a younger state.
Want to Learn More About NMN?
Learn the basics about NMN here
Learn more about the difference between NMN and NR here.
Learn the real science behind NMN here
Understand how to store NMN to maintain its effectiveness here
Learn more about the anti-aging supplement NOVOS Boost, containing high-quality, high-purity NMN
